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Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disorder caused by the aggregation of amyloid-beta (Aβ) at outside of neuron cells and also due to tau aggregation inside the cell. Corosolic acid is aimed to be selected as a main active constituent of Lagerstroemia speciosa for the study.

In the present study, molecular docking of corosolic acid and tau protein was examined using PyRx-v.0.8 software. Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties were described and a molecular dynamics study of the bound complex was performed using Desmond.

The docking score and interactions suggested that the corosolic acid (CID:6918774) could bind to tau protein to prevent the fibrillar network, to prevent AD. During simulation corosolic acid-bound protein root mean square deviation (RMSD) values showed more stability when compared to the Apo form of protein. Molecular dynamics study of tau protein and corosolic acid complex gave the insights to develop a drug-like candidate against AD.

The use of corosolic acid of Lagerstroemia speciosa to prevent AD is supported by preliminary analysis on a computational basis. This compound should explore in terms of experimental strategies for the further drug development process. However, in vitro and in vivo evaluation studies are required to suggest the use of corosolic acid against AD.

In the last four years, since Volume I of this Bibliography first appeared, there has been an explosion of literature in all the main functional areas of business. This wealth of material poses problems for the researcher in management studies — and, of course, for the librarian: uncovering what has been written in any one area is not an easy task. This volume aims to help the librarian and the researcher overcome some of the immediate problems of identification of material. It is an annotated bibliography of management, drawing on the wide variety of literature produced by MCB University Press. Over the last four years, MCB University Press has produced an extensive range of books and serial publications covering most of the established and many of the developing areas of management. This volume, in conjunction with Volume I, provides a guide to all the material published so far.

The COVID pandemic has prompted B2B and industrial marketing scholars to understand more about how external disruptions impact parties involved in B2B transactions. This paper aims to adopt an ecosystem perspective to conceptually classify the interactions between actors involved in B2B ecosystems.

This conceptual paper presents a framework across multiple levels of ecosystem interactions (at micro, meso and macrolevels) to illustrate how value cocreation and knowledge flows (as mechanisms underlying B2B relationships) are related to firm performance.

Based on this framework, this paper offers propositions and several research questions about the effects of disruptions and how they propagate among these essential business ecosystem elements.

This conceptual framework underscores the vital role of relationships and interactions in shaping B2B ecosystems, especially during disruptive periods. With a greater understanding of how these interactions operate across levels (micro, meso and macro), scholars and practitioners may be better able to navigate disruptive periods.

This study evaluates the factors related to the creation of a human brand in the brand inception stage.

Employing content analysis of expert reviews, we establish the role played by valence (positiveness), depth (number of statements) and timing of subjective and objective critical reviews for human brands. To address these issues, we employ generalized estimating equations to model numerical ratings of celebrity reviews evaluating a nascent human brand.

The findings show that subjective reviews have the potential to influence the probability of survival of a human brand in the brand inception period, are increasingly consequential during the inception period stages and are more influential than objective reviews. We also found that the valence of objective reviews can negatively and significantly relate to human brands in their late inception stage.

This is the first research to demonstrate the importance of critical reviews in building human brands, with a focus on the first moment of a brand's inception. More importantly, this research enriches our understanding of the larger process of personal brand building as it may emerge over time.

Reviews a real‐life investigation carried out on copper coating of CO⊂2 welding wire. The major quality problems were non‐uniformity in coating thickness and other associated problems. The factors identified as responsible are speed of drawing the wire, acid, ferrous and copper sulphate. Describes three stages of the study. The results obtained revealed a number of interesting facts about the process. The extent to which the copper coating is influenced by these factors independently and interactively was vividly brought out by factorial experiments, fractional factorial experiments and standard orthogonal arrays. These results show various intricate dynamics of interest to a process controller.

Based on persuasion theories, the purpose of this paper is to examine relationships between four types of interactive consumer activities (viewing, liking, sharing and commenting) on hotel brand social networking sites (SNSs) and their cognitive and emotional responses to understand the psychological states underlying such actions and assess their influence on brand attitude and the brand–consumer relationship.

A survey was administrated using an online platform. Participants who had been following a hotel brand on any of its SNSs were screened to fill out the questionnaire. Eventually, 226 valid responses were collected and analyzed using structure equation modeling.

The findings suggest that although both emotional and cognitive involvement can enhance a consumer’s hotel brand attitude, cognitive involvement is associated with a slightly stronger effect in the context of SNSs. Three of the four interactive actions – viewing, liking and sharing – were found to be positively associated with emotional involvement, but only two actions – viewing and liking – were found to be positively related to cognitive involvement. No connection was identified for commenting.

The study suggests that practitioners should turn their attention to the emotional and cognitive responses their SNSs provoke in consumers, rather than simply on the number of likes, shares and comments they induce.

A recent research trend indicates widespread interest in the button functions offered by SNSs (such as “like,” “share” and “comment”) and many studies have tested means of stimulating such physical actions. This study is one of the few to explore the psychological states behind such actions and assess their influence on brand attitude and the self-brand connection.

The purpose of this study is to investigate the interactive effects of a firm’s strategic sustainability orientation (SSO) and customer relationship capital (CRC) on sustainable product design practices (SPDP).

The authors examine the interactive effects of two firm resources, namely, SSO and CRC, as they relate to SPDP, using survey data from 132 manufacturers in Malaysia.

The findings show that the effect of SSO on SPDP is stronger when CRC is low, than otherwise. The authors also find that the interactive effects of the firm-level resources stated above are stronger when customer pressures (CPs) are higher than when they are low.

The authors contribute to the literature by studying the effects of firm-level strategic resources and their interactions as they relate to SPDP. An important limitation of this research is the usage of single-source data and single-period data.

Managerially, this research provides new insights into how organizations should respond to CPs while understanding the counterintuitive but disabling effects of customer relationship assets.

The findings are important to society because most of the environmental impact arising from the production, consumption and disposal of products is a direct consequence of decisions made at the product design stage and an unintended consequence of the marketing decision-making processes that underlie marketing strategy formulation that fails to recognize ecosystems impact as a standard decision influence.

To the best of the authors’ knowledge, this research is the first to study the effects of firm-level strategic resources and their interactions as they relate to SPDP.

“GIVE a dog a bad name and hang him,” is an aphorism which has been accepted for many years. But, like many other household words, it is not always true. Even if it were, the dog to be operated upon would probably prefer a gala day at his Tyburn Tree to being executed in an obscure back yard.